During the Medieval times, the Colosseum suffered some radical changes, becoming a place for religious rituals. A small church was build around 6th century and the arena was converted into a cemetery.
The great earthquake in 1349 caused great damages to the amphitheatre. The outer south part even collapsed.
Starting 14th century, the Coloseum became home for a religious order. Many stones coming from the monument were used for other constructions.
Some researchers consider that the Martyrdom of Saint Ignatius of Antioch, took place in the Colosseum.